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Article

Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome.

Physiology & behavior - 15 Sept 2004

Hampton Thomas G, Stasko Melissa R, Kale Ajit, Amende Ivo, Costa Alberto C S

Abstract excerpt

The segmentally trisomic mouse Ts65Dn is a model of Down syndrome (DS). Gait abnormalities are almost universal in persons with DS. We applied a noninvasive imaging method to quantitatively compare the gait dynamics of Ts65Dn mice (n=10) to their euploid littermates (controls) (n=10). The braking duration of the hind limbs in Ts65Dn mice was prolonged compared to that in control mice (60+/-3 ms vs. 49+/-2 ms,...

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Identifiers

PMID: 15276802
DOI: 10.1016/j.physbeh.2004.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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