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Article

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

PloS one - 1 Jan 2015

Belichenko Pavel V, Kleschevnikov Alexander M, Becker Ann, Wagner Grant E, Lysenko Larisa V, Yu Y Eugene, Mobley William C

Abstract excerpt

Down syndrome (DS), trisomy for chromosome 21, is the most common genetic cause of intellectual disability. The genomic regions on human chromosome 21 (HSA21) are syntenically conserved with regions on mouse chromosomes 10, 16, and 17 (Mmu10, Mmu16, and Mmu17). Recently, we created a genetic model of DS which carries engineered duplications of all three mouse syntenic regions homologous to HSA21. This 'triple...

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Identifiers

PMID: 26230397
DOI: 10.1371/journal.pone.0134861
PMCID: PMC4521889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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