Article

Ts66Yah, an upgraded Ts65Dn mouse model for Down syndrome, for only the region homologous to Human chromosome 21

2022-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Down syndrome is caused by trisomy of human chromosome 21 (Hsa21). The understanding of phenotype-genotype relationships, the identification of driver genes and various proof-of-concepts for therapeutics have benefited from mouse models. The premier model, named Ts(17 16 )65Dn/J (Ts65Dn), displayed phenotypes related to the human DS features. It carries an additional minichromosome with the Mi...

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Literature Corpus work: c25f862f-029e-5936-a5ea-53b7750ae871
DOI: 10.1101/2022.06.06.494940

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