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Article

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2011

Duchon Arnaud, Raveau Matthieu, Chevalier Claire, Nalesso Valérie, Sharp Andrew J, Herault Yann

Abstract excerpt

Down syndrome (DS) is the most frequent genetic disorder leading to intellectual disabilities and is caused by three copies of human chromosome 21. Mouse models are widely used to better understand the physiopathology in DS or to test new therapeutic approaches. The older and the most widely used mouse models are the trisomic Ts65Dn and the Ts1Cje mice. They display deficits similar to those observed in DS...

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Share to Comparative Genomic Hybridization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21953411
DOI: 10.1007/s00335-011-9356-0
PMCID: PMC3224224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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