Article

Systematic Functional Characterization of Human 21st Chromosome Orthologs in <i>Caenorhabditis elegans</i>

2017-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Individuals with Down syndrome have neurological and muscle impairments due to an additional copy of the human 21 st chromosome (HSA21). Only a few of ~200 HSA21 genes encoding protein have been linked to specific Down syndrome phenotypes, while the remainder are understudied. To identify poorly characterized HSA21 genes required for nervous system function, we studied behavioral phenotypes cau...

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Literature Corpus work: bb546ffd-eefe-5df7-bce5-f09aaf0c0b4f
DOI: 10.1101/136911

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