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Article

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

27 Jan 2009

Abstract excerpt

Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O'Doherty et al. [An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309 (2005) 2033-2037] generated a trans-species aneuploid mouse line (Tc1) that carries an almost complete Hsa21. The Tc1 mouse is the most complete animal model for DS currently...

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PMID: 19181682
DOI: 10.1093/hmg/ddp055

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