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Article

Tau positron emission tomography imaging in tauopathies: The added hurdle of off‐target binding

1 Jan 2018

Abstract excerpt

Ligands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with Alzheimer's disease and related non-Alzheimer's disease tauopathies. Several candidate compounds have been developed, showing good in vitro characteristics with respect to their ability to bind tau deposits; off-target binding,...

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PMID: 29780868
DOI: 10.1016/j.dadm.2018.01.007

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