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Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

14 Jun 2024

Abstract excerpt

Abstract Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for imaging non-AD tauopathies. Here we show the properties of analogues of a first-in-class 4R-tau lead, [ 18 F]OXD-2115, using ligand-based design. Over 150 analogues of...

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PMID: 38877019
DOI: 10.1038/s41467-024-49258-1

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