Article

Levosimendan inhibits disulfide tau oligomerization ameliorating tau pathology in TauP301L-BiFC mice

2022-08-19

Abstract excerpt

<title>Abstract</title> <p>Tau oligomers play critical roles in tau pathology, responsible for neuronal cell death and transmitting the disease in the brain. Accordingly, preventing tau oligomerization becomes an important therapeutic strategy to treat tauopathies including Alzheimer’s disease. However, progress has been slow due to difficulties of detecting tau oligomers in cellular context. Toward tau-targeted...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7bedf5a-2653-5a1b-9734-49954b00e61b
DOI: 10.21203/rs.3.rs-1906311/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Levosimendan inhibits disulfide tau oligomerization ameliorating tau pathology in TauP301L-BiFC miceDOI 10.21203/rs.3.rs-1906311/v1Read

Levosimendan prevents tau pathology by inhibiting disulfide-linked tau oligomerization posing as a promising anti-tau therapeuticsSemantic proximity Read

Molecular Imaging Insights into Neurodegeneration: Focus on Tau PET RadiotracersSemantic proximity Read

Tau AD fragment aggregates proliferate through autocatalytic secondary nucleationSemantic proximity Read

Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer's Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data.Semantic proximity Read

Tau Pathology is Present<i>In Vivo</i>and Develops<i>In Vitro</i>in Sensory Neurons from Human P301S Tau Transgenic Mice: A System for Screening Drugs against TauopathiesSemantic proximity Read

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cellsSemantic proximity Read

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextSemantic proximity Read

Early Detection of Tau PathologySemantic proximity Read

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027Semantic proximity Read

A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathiesSemantic proximity Read

Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis.Semantic proximity Read

Tau positron emission tomography imaging in tauopathies: The added hurdle of off‐target bindingSemantic proximity Read