Article
Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807.
Molecular imaging - 1 Jan 2016
Declercq Lieven, Celen Sofie, Lecina Joan, Ahamed Muneer, Tousseyn Thomas, Moechars Diederik, Alcazar Jesus, Ariza Manuela, Fierens Katleen, Bottelbergs Astrid, Mariën Jonas, Vandenberghe Rik, Andres Ignacio Jose, Van Laere Koen, Verbruggen Alfons, Bormans Guy
Abstract excerpt
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire comparative preclinical data as well as to establish the value of T808 and T807 as benchmark compounds for assessment of binding affinities of eight new/other tau tracers....
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