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Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody.

Molecular imaging and biology - 1 Oct 2024

Wuensche Thomas E, Stergiou Natascha, Mes Iris, Verlaan Mariska, Kooijman Esther J M, Windhorst Albert D, Jensen Allan, Asuni Ayodeji A, Bang-Andersen Benny, van Dongen Guus A M S, Vugts Danielle J, Beaino Wissam

Abstract excerpt

PURPOSE: In the emerging field of antibody treatments for neurodegenerative diseases, reliable tools are needed to evaluate new therapeutics, diagnose and select patients, monitor disease progression, and assess therapy response. Immuno-PET combines the high affinity and exceptional specificity of monoclonal antibodies with the non-invasive imaging technique positron emission tomography (PET). Its application in...

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Share to Amyloid beta-Peptides
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CHO Cells

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Identifiers

PMID: 39093482
DOI: 10.1007/s11307-024-01931-z
PMCID: PMC11436416

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APP
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