Article

A novel small molecule screening platform for disrupting toxic tau oligomers in cells

2019-01-03

Abstract excerpt

Tauopathies, including Alzheimer’s disease, are a group of neurodegenerative disorders characterized by pathological aggregation of the microtubule binding protein tau. Recent studies suggest that toxic tau oligomers, which are soluble and distinct from insoluble beta-sheet fibrils, are central players in neuronal cell death. To exploit this new therapeutic window, we engineered two first-in-class FRET based biose...

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Literature Corpus work: 6d9c5312-5264-5a7a-b80f-1b2b474d488c
DOI: 10.1101/510412

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