Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non-For-Profit Scientific Management.

Chembiochem : a European journal of chemical biology - 3 Jun 2024

Dickmann Catherine G F, Milicevic Sephton Selena, Barker Roger A, Aigbirhio Franklin I

Abstract excerpt

Positron emission tomography imaging of misfolded proteins with high-affinity and selective radioligands has played a vital role in expanding our knowledge of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. The pathogenesis of Huntington's disease, a CAG trinucleotide repeat disorder, is similarly linked to the presence of protein fibrils formed from mutant huntingtin (mHTT) protein....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Huntingtin Protein
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Mutation

Share to Positron-Emission Tomography

Share to Protein Aggregates

Share to Radiopharmaceuticals

Source

Identifiers

PMID: 38695673
DOI: 10.1002/cbic.202400152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non-For-Profit Scientific Management.PMID 38695673Read ↗

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.Semantic proximity Read ↗

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidatesSemantic proximity Read ↗

Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s diseaseSemantic proximity Read ↗

A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington’s diseaseSemantic proximity Read ↗

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of HuntingtinSemantic proximity Read ↗

A Positron Emission Tomography Ligand for Mutant Huntingtin Sheds Light on Disease.Semantic proximity Read ↗

Highly Potent Peptide Therapeutics To Prevent Protein Aggregation In Huntington’s DiseaseSemantic proximity Read ↗

Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells.Semantic proximity Read ↗

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 ComplexSemantic proximity Read ↗

Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cellsSemantic proximity Read ↗

Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s diseaseSemantic proximity Read ↗

Targeting mutant huntingtin for the development of disease-modifying therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.