Deiodinases share an evolutionarily conserved thyroid hormone-binding motif.

Abstract excerpt

Human and animal thyroid hormone (TH) plasma carriers (THPC, n=426), cell surface TH transporters (CSTT, n=8,691), and TH nuclear receptors (TR, n=624) share a 49-position long TH-binding motif. Particularly conserved are positions 22-26, where a 5-residue TH-binding motif was originally detected. We extended our research to the 488 sequences of human and animal selenodeiodinases (dio-1, dio-2, dio-3).  In the...

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