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Article

Biochemical mechanisms of thyroid hormone deiodination.

Thyroid : official journal of the American Thyroid Association - 1 Aug 2005

Kuiper George G J M, Kester Monique H A, Peeters Robin P, Visser Theo J

Abstract excerpt

Deiodination is the foremost pathway of thyroid hormone metabolism not only in quantitative terms but also because thyroxine (T(4)) is activated by outer ring deiodination (ORD) to 3,3',5-triiodothyronine (T(3)), whereas both T(4) and T(3) are inactivated by inner ring deiodination (IRD) to 3,3',5-triiodothyronine and 3,3'-diiodothyronine, respectively. These reactions are catalyzed by three iodothyronine...

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Identifiers

PMID: 16131322
DOI: 10.1089/thy.2005.15.787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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