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Article

A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

The Journal of clinical endocrinology and metabolism - 1 Aug 2008

Panicker Vijay, Cluett Christie, Shields Beverley, Murray Anna, Parnell Kirstie S, Perry John R B, Weedon Michael N, Singleton Andrew, Hernandez Dena, Evans Jonathan, Durant Claire, Ferrucci Luigi, Melzer David, Saravanan Ponnusamy, Visser Theo J, Ceresini Graziano, Hattersley Andrew T, Vaidya Bijay, Dayan Colin M, Frayling Timothy M

Abstract excerpt

INTRODUCTION: Genetic factors influence circulating thyroid hormone levels, but the common gene variants involved have not been conclusively identified. The genes encoding the iodothyronine deiodinases are good candidates because they alter the balance of thyroid hormones. We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18492748
DOI: 10.1210/jc.2008-0397
PMCID: PMC2515080

Genes

DIO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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