Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective.

doi:10.1007/s40618-020-01287-5

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Article

Thr92Ala polymorphism in the type 2 deiodinase gene: an evolutionary perspective.

Journal of endocrinological investigation - 1 Dec 2020

Ricci C, Kakularam K R, Marzocchi C, Capecchi G, Riolo G, Boschin F, Kuhn H, Castagna M G, Cantara S

Abstract excerpt

PURPOSE: In the past, a role of thyroid hormones in human evolution has been hypothesized. T3, the metabolically active form, derives from extrathyroidal conversion of T4 by deionidase 2 (D2) enzyme encoded by DIO2 gene. In thyroid-deficient patients, decreased levels of free T3 have been associated with the polymorphism rs225014 A/G in DIO2, which causes the substitution of Threonine with Alanine (p.Thr92Ala) at...

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PMID: 32436183
DOI: 10.1007/s40618-020-01287-5

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