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Article

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.

The Journal of biological chemistry - 19 Sept 2003

Callebaut Isabelle, Curcio-Morelli Cyntia, Mornon Jean-P, Gereben Balazs, Buettner Christoph, Huang Stephen, Castro Bertrand, Fonseca Tatiana L, Harney John W, Larsen P Reed, Bianco Antonio C

Abstract excerpt

The three iodothyronine selenodeiodinases catalyze the initiation and termination of thyroid hormone effects in vertebrates. Structural analyses of these proteins have been hindered by their integral membrane nature and the inefficient eukaryotic-specific pathway for selenoprotein synthesis. Hydrophobic cluster analysis used in combination with Position-specific Iterated BLAST reveals that their extramembrane...

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PMID: 12847093
DOI: 10.1074/jbc.M305725200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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