Article
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Nature - 1 Oct 2022
Matsuzawa-Ishimoto Yu, Yao Xiaomin, Koide Akiko, Ueberheide Beatrix M, Axelrad Jordan E, Reis Bernardo S, Parsa Roham, Neil Jessica A, Devlin Joseph C, Rudensky Eugene, Dewan M Zahidunnabi, Cammer Michael, Blumberg Richard S, Ding Yi, Ruggles Kelly V, Mucida Daniel, Koide Shohei, Cadwell Ken
Abstract excerpt
Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial barrier and is associated with Crohn's disease, a major type of inflammatory bowel disease1-7. Non-classical lymphoid cells, broadly referred to as intraepithelial lymphocytes (IELs), intercalate the intestinal epithelium8,9. This anatomical position has implicated them as first-line defenders in resistance to infections,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.