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Article

Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine.

Scientific reports - 29 Jan 2021

Lindblad Jillian L, Tare Meghana, Amcheslavsky Alla, Shields Alicia, Bergmann Andreas

Abstract excerpt

The initiator caspase Dronc is the only CARD-domain containing caspase in Drosophila and is essential for apoptosis. Here, we report that homozygous dronc mutant adult animals are short-lived due to the presence of a poorly developed, defective and leaky intestine. Interestingly, this mutant phenotype can be significantly rescued by enteroblast-specific expression of dronc+ in dronc mutant animals, suggesting...

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Identifiers

PMID: 33514791
DOI: 10.1038/s41598-021-81261-0
PMCID: PMC7846589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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