Article
Coreceptor Tropism and Maraviroc Sensitivity of Clonally Derived Ethiopian HIV-1C Strains Using an in-house Phenotypic Assay and Commonly Used Genotypic Methods.
Current HIV research - 1 Jan 2018
Kalu Amare Worku, Telele Nigus Fikrie, Aralaguppe Shambhu G, Gebre-Selassie Solomon, Fekade Daniel, Marrone Gaetano, Sonnerborg Anders
Abstract excerpt
OBJECTIVES: Genotypic Tropism Testing (GTT) tools are generally developed based on HIV-1 subtype B (HIV-1B) and used for HIV-1C as well but with a large discordance of prediction between different methods. We used an established phenotypic assay for comparison with GTT methods and for the determination of in vitro maraviroc sensitivity of pure R5-tropic and dual-tropic HIV-1C. METHODS: Plasma was obtained from 58...
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