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Article

Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa.

Scientific reports - 5 Feb 2018

Siddik Abu Bakar, Haas Alexandra, Rahman Md Shanawazur, Aralaguppe Shambhu Ganeshappa, Amogne Wondwossen, Bader Joelle, Klimkait Thomas, Neogi Ujjwal

Abstract excerpt

Genotypic tropism testing (GTT) for co-receptor usage is a recommended tool for clinical practice before administration of the CCR5-antagonist maraviroc. For some isolates, phenotypic tropism testing (PTT) revealed discordant results with GTT. In this study, we performed a comparative study between GTT and PTT in HIV-1C from East Africa (HIV-1CEA) and compared the data with HIV-1B and 01_AE and described the...

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Identifiers

PMID: 29403064
DOI: 10.1038/s41598-018-20814-2
PMCID: PMC5799384

Genes

CCR5

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