Article
Performance of commonly used genotypic assays and comparison with phenotypic assays of HIV-1 coreceptor tropism in acutely HIV-1-infected patients.
The Journal of antimicrobial chemotherapy - 1 May 2015
Ceresola Elisa Rita, Nozza Silvia, Sampaolo Michela, Pignataro Angela Rosa, Saita Diego, Ferrarese Roberto, Ripa Marco, Deng Wenjie, Mullins James I, Boeri Enzo, Tambussi Giuseppe, Toniolo Antonio, Lazzarin Adriano, Clementi Massimo, Canducci Filippo
Abstract excerpt
OBJECTIVES: Although founder viruses in primary HIV-1 infections (PHIs) typically use the CCR5 coreceptor (R5-tropic), 3%-19% of subjects also harbour CXCR4-using viruses (X4-tropic), making tropism determination before CCR5 antagonist usage mandatory. Genotypic methods can be used to accurately determine HIV-1 tropism in chronically infected patients. METHODS: We compared the results of genotypic methods...
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