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Genotypic determination of HIV tropism - clinical and methodological recommendations to guide the therapeutic use of CCR5 antagonists.

AIDS reviews - 1 Jan 2000

Poveda Eva, Alcamí José, Paredes Roger, Córdoba Juan, Gutiérrez Félix, Llibre Josep María, Delgado Rafael, Pulido Federico, Iribarren José Antonio, García Deltoro Miguel, Hernández Quero José, Moreno Santiago, García Federico

Abstract excerpt

The approval of maraviroc (Selzentri®), the first CCR5 antagonist, with specific antiviral activity against CCR5 (R5)-tropic HIV variants, has promoted the determination of HIV coreceptor usage in the clinical setting. The phenotypic assay Trofile™, which is based on recombinant virus technology, has been the most widely used diagnostic test, given that it was the only assay which provided tropism information in...

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PMID: 20842202

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CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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