Article
Determination of HIV tropism and its use in the clinical practice.
Expert review of anti-infective therapy - 1 Dec 2013
Pérez-Olmeda Mayte, Alcami José
Abstract excerpt
Assessment of HIV coreceptor tropism assay is recommended before starting therapy with CCR5 coreceptor antagonists. So far, only maraviroc (MVC) has been approved for clinical use and a tropism assay is mandatory for patients with virological failure or patients in which MVC is considered into future treatment options. Viral tropism can be assessed with either genotypic or phenotypic methods and to this aim...
Topics
- Biological Assay
- Cyclohexanes
- Genotype
- HIV Fusion Inhibitors
- HIV Infections
- HIV-1
- Host-Pathogen Interactions
- Humans
- Maraviroc
- Molecular Typing
- Phenotype
- Receptors, CCR5