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Article

Update on clinical and methodological recommendations for genotypic determination of HIV tropism to guide the usage of CCR5 antagonists.

AIDS reviews - 1 Jan 2000

Poveda Eva, Paredes Roger, Moreno Santiago, Alcamí José, Córdoba Juan, Delgado Rafael, Gutiérrez Félix, Llibre Josep M, García Deltoro Miguel, Hernández-Quero José, Pulido Federico, Iribarren José Antonio, García Federico

Abstract excerpt

The genotypic determination of HIV tropism to guide the use of maraviroc, the first CCR5 antagonist with specific antiviral activity against CCR5 (R5)-tropic HIV variants, has been widespread in the last two years. Retrospective analyses from maraviroc clinical trials (MOTIVATE and MERIT) demonstrated that specific genotypic tools and the phenotypic assay TrofileTM are comparable in predicting virologic response...

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PMID: 22833064

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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