Article
The influence of sex, ethnicity, and CYP2B6 genotype on bupropion metabolism as an index of hepatic CYP2B6 activity in humans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2013
Ilic Katarina, Hawke Roy L, Thirumaran Ranjit K, Schuetz Erin G, Hull J Heyward, Kashuba Angela D M, Stewart Paul W, Lindley Celeste M, Chen Mei-Ling
Abstract excerpt
The effects of sex, ethnicity, and genetic polymorphism on hepatic CYP2B6 (cytochrome P450 2B6) expression and activity were previously demonstrated in vitro. Race/ethnic differences in CYP2B6 genotype and phenotype were observed only in women. To identify important covariates associated with interindividual variation in CYP2B6 activity in vivo, we evaluated these effects in healthy volunteers using bupropion...
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