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Article

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.

American journal of human genetics - 7 Jun 2018

Ni Guiyan, Moser Gerhard, Wray Naomi R, Lee S Hong

Abstract excerpt

Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively reduced computing burden of LDSC compared to GREML makes it an attractive tool, although the accuracy (i.e.,...

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Identifiers

PMID: 29754766
DOI: 10.1016/j.ajhg.2018.03.021
PMCID: PMC5993419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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