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Article

Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation.

American journal of human genetics - 5 May 2022

Song Shuang, Jiang Wei, Zhang Yiliang, Hou Lin, Zhao Hongyu

Abstract excerpt

Heritability is a fundamental concept in genetic studies, measuring the genetic contribution to complex traits and bringing insights about disease mechanisms. The advance of high-throughput technologies has provided many resources for heritability estimation. Linkage disequilibrium (LD) score regression (LDSC) estimates both heritability and confounding biases, such as cryptic relatedness and population...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35421325
DOI: 10.1016/j.ajhg.2022.03.013
PMCID: PMC9118121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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