Article

Estimation of genetic correlation using linkage disequilibrium score regression and genomic restricted maximum likelihood

2017-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e. linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively reduced computing burden of LDSC compared to GREML makes it an attractive tool, although the accura...

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Literature Corpus work: 95adea51-19bd-5898-a139-9a945ea614b7
DOI: 10.1101/194019

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