Article
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.
Nature genetics - 1 Oct 2015
Yang Jian, Bakshi Andrew, Zhu Zhihong, Hemani Gibran, Vinkhuyzen Anna A E, Lee Sang Hong, Robinson Matthew R, Perry John R B, Nolte Ilja M, van Vliet-Ostaptchouk Jana V, Snieder Harold, Esko Tonu, Milani Lili, Mägi Reedik, Metspalu Andres, Hamsten Anders, Magnusson Patrik K E, Pedersen Nancy L, Ingelsson Erik, Soranzo Nicole, Keller Matthew C, Wray Naomi R, Goddard Michael E, Visscher Peter M
Abstract excerpt
We propose a method (GREML-LDMS) to estimate heritability for human complex traits in unrelated individuals using whole-genome sequencing data. We demonstrate using simulations based on whole-genome sequencing data that ∼97% and ∼68% of variation at common and rare variants, respectively, can be captured by imputation. Using the GREML-LDMS method, we estimate from 44,126 unrelated individuals that all ∼17 million...
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