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Article

Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships.

BMC bioinformatics - 27 Jul 2022

De Vlaming Ronald, Slob Eric A W, Groenen Patrick J F, Rietveld Cornelius A

Abstract excerpt

BACKGROUND: Heritability and genetic correlation can be estimated from genome-wide single-nucleotide polymorphism (SNP) data using various methods. We recently developed multivariate genomic-relatedness-based restricted maximum likelihood (MGREML) for statistically and computationally efficient estimation of SNP-based heritability ([Formula: see text]) and genetic correlation ([Formula: see text]) across many...

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PMID: 35896974
DOI: 10.1186/s12859-022-04835-3
PMCID: PMC9327374

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