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Article

Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits.

HGG advances - 13 Jul 2023

Bahda Meriem, Ricard Jasmin, Girard Simon L, Maziade Michel, Isabelle Maripier, Bureau Alexandre

Abstract excerpt

Genetic correlations between human traits and disorders such as schizophrenia (SZ) and bipolar disorder (BD) diagnoses are well established. Improved prediction of individual traits has been obtained by combining predictors of multiple genetically correlated traits derived from summary statistics produced by genome-wide association studies, compared with single trait predictors. We extend this idea to penalized...

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Genome-Wide Association Study
Genotype
Phenotype
Risk Factors
Schizophrenia

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PMID: 37333772
DOI: 10.1016/j.xhgg.2023.100209
PMCID: PMC10276147

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