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Article

HIV-1 Matrix Protein Interactions with tRNA: Implications for Membrane Targeting.

Journal of molecular biology - 6 Jul 2018

Gaines Christy R, Tkacik Emre, Rivera-Oven Amalia, Somani Phoebe, Achimovich Alecia, Alabi Tawakalitou, Zhu Angela, Getachew Noel, Yang Ae Lim, McDonough Matthew, Hawkins Tarik, Spadaro Zoe, Summers Michael F

Abstract excerpt

The N-terminally myristoylated matrix (MA) domain of the HIV-1 Gag polyprotein promotes virus assembly by targeting Gag to the inner leaflet of the plasma membrane. Recent studies indicate that, prior to membrane binding, MA associates with cytoplasmic tRNAs (including tRNALys3), and in vitro studies of tRNA-dependent MA interactions with model membranes have led to proposals that competitive tRNA interactions...

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Share to Calorimetry
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

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Share to Phosphatidylinositol 4,5-Diphosphate

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Source

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Identifiers

PMID: 29752967
DOI: 10.1016/j.jmb.2018.04.042
PMCID: PMC6051522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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