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Article

Identification of Non-basic Matrix Domain Residues That Impact HTLV-1 Gag Membrane Targeting and Particle Release.

Journal of molecular biology - 1 Sept 2026

Meng Shuyu, Pham Bao, Hines Sophie, Angert Isaac, Piotter Dalton W, Mueller Joachim D, Saad Jamil S, Zhang Wei, Mansky Louis M

Abstract excerpt

The matrix (MA) domain of the Gag polyprotein is critical for directing retroviral assembly at the plasma membrane (PM), yet the determinants mediating human T-cell leukemia virus type 1 (HTLV-1) Gag targeting remain incompletely defined. While Gag myristoylation and basic residue-mediated electrostatic interactions are known to be crucial for Gag-PM interactions, recent evidence with HTLV-1 MA has implicated...

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Identifiers

PMID: 42031325
DOI: 10.1016/j.jmb.2026.169826
PMCID: PMC13180280

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