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Article

Structural basis of the association of HIV-1 matrix protein with DNA.

PloS one - 23 Dec 2010

Cai Mengli, Huang Ying, Craigie Robert, Clore G Marius

Abstract excerpt

HIV-1 matrix (MA) is a multifunctional protein that is synthesized as a polyprotein that is cleaved by protease during viral maturation. MA contains a cluster of basic residues whose role is controversial. Proposed functions include membrane anchoring, facilitating viral assembly, and directing nuclear import of the viral DNA. Since MA has been reported to be a component of the preintegration complex (PIC), we...

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Identifiers

PMID: 21203471
DOI: 10.1371/journal.pone.0015675
PMCID: PMC3009736

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