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Article

Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41.

Journal of molecular biology - 6 Mar 2014

Sun Zhen-Yu J, Cheng Yuxing, Kim Mikyung, Song Likai, Choi Jaewon, Kudahl Ulrich J, Brusic Vladimir, Chowdhury Barnali, Yu Lu, Seaman Michael S, Bellot Gaëtan, Shih William M, Wagner Gerhard, Reinherz Ellis L

Abstract excerpt

HIV-1 (human immunodeficiency virus type 1) uses its trimeric gp160 envelope (Env) protein consisting of non-covalently associated gp120 and gp41 subunits to mediate entry into human T lymphocytes. A facile virus fusion mechanism compensates for the sparse Env copy number observed on viral particles and includes a 22-amino-acid, lentivirus-specific adaptation at the gp41 base (amino acid residues 662-683), termed...

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Identifiers

PMID: 24075869
DOI: 10.1016/j.jmb.2013.09.030
PMCID: PMC3934758

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