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Article

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane.

Viruses - 24 Apr 2020

Wijesinghe Kaveesha J, McVeigh Luke, Husby Monica L, Bhattarai Nisha, Ma Jia, Gerstman Bernard S, Chapagain Prem P, Stahelin Robert V

Abstract excerpt

Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane. VP40 traffics to the plasma membrane inner leaflet, where it assembles to facilitate the budding of viral particles. VP40 is a...

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Identifiers

PMID: 32344654
DOI: 10.3390/v12040482
PMCID: PMC7232359

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Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane.PMID 32344654Read ↗

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