Article
Membrane structure correlates to function of LLP2 on the cytoplasmic tail of HIV-1 gp41 protein.
Biophysical journal - 6 Aug 2013
Boscia Alexander L, Akabori Kiyotaka, Benamram Zachary, Michel Jonathan A, Jablin Michael S, Steckbeck Jonathan D, Montelaro Ronald C, Nagle John F, Tristram-Nagle Stephanie
Abstract excerpt
Mutation studies previously showed that the lentivirus lytic peptide (LLP2) sequence of the cytoplasmic C-terminal tail of the HIV-1 gp41 envelope protein inhibited viral-initiated T-cell death and T-cell syncytium formation, at which time in the HIV life cycle the gp41 protein is embedded in the T-cell membrane. In striking contrast, the mutants did not affect virion infectivity, during which time the gp41...
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