Article
Structural and Mechanistic Studies of the Rare Myristoylation Signal of the Feline Immunodeficiency Virus.
Journal of molecular biology - 26 Jun 2020
Brown Janae B, Summers Holly R, Brown Lola A, Marchant Jan, Canova Paige N, O'Hern Colin T, Abbott Sophia T, Nyaunu Constance, Maxwell Simon, Johnson Talayah, Moser Morgan B, Ablan Sherimay D, Carter Hannah, Freed Eric O, Summers Michael F
Abstract excerpt
All retroviruses encode a Gag polyprotein containing an N-terminal matrix domain (MA) that anchors Gag to the plasma membrane and recruits envelope glycoproteins to virus assembly sites. Membrane binding by the Gag protein of HIV-1 and most other lentiviruses is dependent on N-terminal myristoylation of MA by host N-myristoyltransferase enzymes (NMTs), which recognize a six-residue "myristoylation signal" with...
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