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Article

Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation.

The Journal of biological chemistry - 1 Jan 2021

Eastep Gunnar N, Ghanam Ruba H, Green Todd J, Saad Jamil S

Abstract excerpt

During the late phase of HIV-1 infection, viral Gag polyproteins are targeted to the plasma membrane (PM) for assembly. Gag localization at the PM is a prerequisite for the incorporation of the envelope protein (Env) into budding particles. Gag assembly and Env incorporation are mediated by the N-terminal myristoylated matrix (MA) domain of Gag. Nonconservative mutations in the trimer interface of MA (A45E, T70R,...

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Share to Cell Membrane
Share to Gene Products, gag
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Multimerization

Share to Viral Matrix Proteins

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Source

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Identifiers

PMID: 33485964
DOI: 10.1016/j.jbc.2021.100321
PMCID: PMC7952133

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