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Structural insights into dynamics of the BMV TLS aminoacylation

3 Feb 2025

Abstract excerpt

Brome Mosaic Virus (BMV) utilizes a tRNA-like structure (TLS) within its 3' untranslated region to mimic host tRNA functions, aiding aminoacylation and viral replication. This study explores the structural dynamics of BMV TLS interacting with tyrosyl-tRNA synthetase (TyrRS) during aminoacylation. Using cryo-EM, we capture multiple states of the TLS-TyrRS complex, including unbound TLS, pre-1a, post-1a, and...

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PMID: 39900568
DOI: 10.1038/s41467-025-56612-4

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