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Article

Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2018

Fernando Roshini, Grisolia Ana Beatriz Diniz, Lu Yan, Atkins Stephen, Smith Terry J

Abstract excerpt

Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator...

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Source

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Identifiers

PMID: 29752312
DOI: 10.4049/jimmunol.1800259
PMCID: PMC6070359

Genes

AIRE
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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