Article
Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.
Thyroid : official journal of the American Thyroid Association - 1 Sept 2008
Smith Terry J, Tsai Chieh Chih, Shih Mei-Ju, Tsui Shanli, Chen Beiling, Han Rui, Naik Vibha, King Chris S, Press Chris, Kamat Shweta, Goldberg Robert A, Phipps Richard P, Douglas Raymond S, Gianoukakis Andrew G
Abstract excerpt
Tissue remodeling associated with thyroid-associated ophthalmopathy (TAO) involves the complex interplay between resident cells (endothelium, vascular smooth muscle, extraocular muscle, and fibroblasts) and those recruited to the orbit, including members of the "professional" immune system. Inflammation early in the disease can later culminate in fibrosis and diminished extraocular muscle motility. TAO remains a...
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