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Article

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy.

Frontiers in endocrinology - 1 Jan 2022

Wu Pengsen, Lin Bingying, Huang Siyu, Meng Jie, Zhang Fan, Zhou Min, Hei Xiangqing, Ke Yu, Yang Huasheng, Huang Danping

Abstract excerpt

Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression pattern of IL-11 in patients with TAO and whether IL-11 is mechanistically linked with pathological fibrosis remains unknown. In this study, we investigated...

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Identifiers

PMID: 35273577
DOI: 10.3389/fendo.2022.846106
PMCID: PMC8902078

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