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Article

Orbital Fibroblasts Exhibit a Novel Pattern of Responses to Proinflammatory Cytokines: Potential Basis for the Pathogenesis of Thyroid-Associated Ophthalmopathy

1 Mar 2002

Abstract excerpt

Thyroid-associated ophthalmopathy (TAO) represents a process confined to the orbit where the connective tissue becomes inflamed and accumulates the glycosaminoglycan, hyaluronan. Ultimately, the orbital tissues become extensively remodeled. Evidence points to the recruitment and activation of T cells as critical elements initiating and driving the pathogenesis of TAO. The phenotype of orbital fibroblasts appears...

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PMID: 11952039
DOI: 10.1089/105072502753600133

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