Article

TUBB1+ cytotoxic lymphocyte states track disease course in thyroid-associated ophthalmopathy

2026-02-22

Abstract excerpt

<title>Abstract</title> <p> Background Thyroid-associated ophthalmopathy (TAO) is an orbital autoimmune disease related to Graves' disease, pathologically characterized by immune-mediated fibroinflammatory changes, which can lead to facial disfigurement and vision loss. But peripheral immune states linked to tissue remodeling remain unclear, limiting the development of effective therapeutic strategies. Methods...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af3c52df-3ca4-5b15-b3cd-b60df82dc4eb
DOI: 10.21203/rs.3.rs-8898323/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TUBB1+ cytotoxic lymphocyte states track disease course in thyroid-associated ophthalmopathyDOI 10.21203/rs.3.rs-8898323/v1Read

Integrative transcriptomic profiling and machine learning reveal hypoxia-associated molecular signatures for precision diagnosis in thyroid eye diseaseSemantic proximity Read

Mechanisms of immune-related differentially expressed genes in thyroid-associated ophthalmopathy based on the GEO databaseSemantic proximity Read

Immune-parenchymal multicellular niches are shared across distinct thyroid autoimmune diseasesSemantic proximity Read

Dynamic transition of Tregs to cytotoxic phenotype amid systemic inflammation in Graves' ophthalmopathy.Semantic proximity Read

Deciphering the LncRNA-Mediated Gene Regulatory Network and Pathogenic Cascades in Thyroid-Associated OphthalmopathySemantic proximity Read

Exploring Prognostic Gene Expression Signature for Thyroid Eye DiseaseSemantic proximity Read

The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathwaySemantic proximity Read

Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathwaySemantic proximity Read

Leptin receptor is a key gene involved in the immunopathogenesis of thyroid‐associated ophthalmopathySemantic proximity Read

A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves’ orbitopathySemantic proximity Read

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R PathwaySemantic proximity Read

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.Semantic proximity Read