Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F.

Scientific reports - 8 May 2018

Gorenjak Vesna, Aldasoro Arguinano Alex-Ander, Dadé Sébastien, Stathopoulou Maria G, Vance Dwaine R, Masson Christine, Visvikis-Siest Sophie

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-inflammatory properties during the immune response, and influences negatively on TNF-α expression levels. Genetic epidemiology studies have identified polymorphisms located in the TREM2 gene associated with neurodegenerative and chronic inflammatory diseases. TREM2 levels have been observed to affect plasma levels of TNF-α and plaque...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Carotid Intima-Media Thickness

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Femoral Artery

Share to Inflammation

Share to Membrane Glycoproteins

Share to Receptors, Immunologic

Share to Tumor Necrosis Factor-alpha

Share to Tunica Intima

Source

Open in PubMed Open full text

Identifiers

PMID: 29740051
DOI: 10.1038/s41598-018-25553-y
PMCID: PMC5940861

Genes

TNF
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-α levels and IMT-F.PMID 29740051Read ↗

TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin.Semantic proximity Read ↗

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s diseaseSemantic proximity Read ↗

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study.Semantic proximity Read ↗

Variant of TREM2 associated with the risk of Alzheimer's disease.Semantic proximity Read ↗

The <i>MS4A</i> gene cluster is a key regulator of soluble TREM2 and Alzheimer disease riskSemantic proximity Read ↗

TREM2 analysis and increased risk of Alzheimer's disease.Semantic proximity Read ↗

TREM2 coding variants in Slovak Alzheimer's disease patients.Semantic proximity Read ↗

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.Semantic proximity Read ↗

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Semantic proximity Read ↗

The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations.Semantic proximity Read ↗

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers diseaseSemantic proximity Read ↗

Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid-soluble TREM2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.