Article
TREM2 analysis and increased risk of Alzheimer's disease.
Neurobiology of aging - 1 Jan 2015
Finelli Deana, Rollinson Sara, Harris Jenny, Jones Matthew, Richardson Anna, Gerhard Alex, Snowden Julie, Mann David, Pickering-Brown Stuart
Abstract excerpt
Important insights into the pathogenic mechanism of Alzheimer's disease (AD) have arisen from the identification of genetic risk factors. Recently, a variant in the TREM2 gene (rs75932628), causing a C-to-T base-pair change that results in the substitution of histidine for arginine at amino acid position 47 (R47H) in the TREM2 protein, has been associated with an increased risk of AD. We, therefore, genotyped...
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