Article
TREM2 coding variants in Slovak Alzheimer's disease patients.
Journal of integrative neuroscience - 1 Jun 2022
Durmanova Vladimira, Javor Juraj, Parnicka Zuzana, Minarik Gabriel, Ocenasova Agata, Vaseckova Barbora, Kiralyova Iliana, Sutovsky Stanislav, Petrovic Robert, Shawkatova Ivana
Abstract excerpt
BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of inflammation. TREM2 dysfunction has been linked to the pathogenesis of various neurodegenerative diseases including Alzheimer's disease (AD). Rare coding variants of...
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